DEPRESSION AND HYPOTHYROIDISM IN ANIMAL MODELS

Hypothyroidism is one of the common diseases worldwide that occurs when thyroid gland unable to produce enough hormone for body's metabolic needs. Thyroid hormones play a critical role in activity brain, and hypothyroidism has important effects on neuropsychiatric function. The incidence depressive syndrome higher patients with hypothyroidism. However, mechanism depression other psychiatric disorders caused by stil unclear. symptomatic manifestations are diverse it possible model many them experimental animal models. Studies have shown hypothyroid animals more likely develop like behaviors compared euthyroid controls. In these studies, much longer immobility time was observed forced swim test rats. It been suggested neurotransmitter systems especially serotonin, involved relationship between symptoms. Since prevalence high clinical practice, symptoms should be considered dysfunction. aim this review examine rodents using test.